ABCC9 gene affects sleep duration
Following the observation that long or short sleep duration is associated with metabolic syndrome, and that sleep duration is affected by season, 'biological clock type' (chronotype (lark/owl)) and human familial disorders led to a German group to do a genetics study in 7 European populations. They found a variant in the ABCC9 gene affected 5% of the variation in sleep duration.
The ABCC9 gene encodes the SUR2 protein which is involved in part of the adenosine triphosphate sensing mechanisms in the cell membrane which appear to be sensors of cell energy metabolism. This protein is also involved in heart disease, diabetes and is associated with body mass index and high blood pressure.
Allebrandt KV, Amin N, Müller-Myhsok B, Esko T, Teder-Laving M, Azevedo RV, Hayward C, van Mill J, Vogelzangs N, Green EW, Melville SA, Lichtner P, Wichmann HE, Oostra BA, Janssens AC, Campbell H, Wilson JF, Hicks AA, Pramstaller PP, Dogas Z, Rudan I, Merrow M, Penninx B, Kyriacou CP, Metspalu A, van Duijn CM, Meitinger T, Roenneberg T.
Mol Psychiatry. 2011 Nov 22. doi: 10.1038/mp.2011.142. [Epub ahead of print]
- PMID:
- 22105623
- [PubMed - as supplied by publisher]
